UNH FInds Repurposed Drug Could Inhibit Enzyme used in COVID-19 Replication

biopharma

Researchers at the University of New Hampshire have recently found that an existing drug compound could be successfully repurposed and used to block the activity of an enzyme of the coronavirus. 

“The goal was to slow or prevent the spread of the virus by using a strategic therapeutic that could possibly disrupt key steps in the viral life cycle at the molecular level, like the first contact with a healthy cell or the first step in replicating within an infected cell,” said Harish Vashisth, associate professor of chemical engineering.

They published their first-of-its-kind study in the journal PROTEINS: Structure, Function, and Bioinformatics. The researchers targeted this key enzyme, the main protease enzyme Mpro, which has become a primary target of intense research and therapeutic development due to its role in the virus’s replication.

They explored the inhibiting properties of a derivative of the existing compound – Thiadiazolidinones (TDZD). TDZD is already being studied as a potential treatment of neurological disorders like Parkinson’ Disease. Using molecular dynamics simulations combined with laboratory experiments, the researchers determined that the TDZD compound was able to inhibit the Mpro enzyme. Preventing the enzyme for working could prevent the virus’s ability to develop defenses at the cellular level.

This research was supported by grants from the National Institutes of Health under award numbers R35GM138217, P20GM113131, and the National Science Foundation under award number OIA-1757371. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funders.

Are you developing new technology for an existing application? Did you know your development work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? Even if your development isn’t successful your work may still qualify for R&D credits (i.e. you don’t need to have a patent to qualify). To find out more, please contact a Swanson Reed R&D Specialist today or check out our free online eligibility test.

Who We Are:

Swanson Reed is one of the U.S.’ largest Specialist R&D tax advisory firms. We manage all facets of the R&D tax credit program, from claim preparation and audit compliance to claim disputes.

Swanson Reed regularly hosts free webinars and provides free IRS CE and CPE credits for CPAs. For more information please visit us at www.swansonreed.com/webinars or contact your usual Swanson Reed representative.

Binarly Raises $3.6M in Seed Funding to Support R&D and Scaling

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Firmware security company Binarly, Inc. on Wednesday announced that it has raised $3.6 million in a seed funding round.Several angel investors took part in the seed round, led by Westwave Capital and Acrobator Ventures. 

The funding will aid in speeding up R&D initiatives, expanding their engineering team, and scaling the adoption of their technologies.

Binarly has developed a SaaS platform designed for firmware threat identification and response. This AI-powered firmware protection platform performs in-depth introspection through a combination of machine learning and code analysis techniques. These techniques are proprietary technologies developed by the company. With this technology, security teams can identify vulnerabilities and malicious firmware modifications. 

“The current approach in the industry is to detect risks related to the firmware by leveraging the current version number of the firmware update against a public database of vulnerabilities and threats. This leads to firmware supply chain failures because known vulnerabilities that are not associated with a certain version number of a firmware release will not be detected, thus keeping the ‘doors’ open for an attacker,” said Alex Matrosov, co-founder and CEO of Binarly.

Binarly has identified firmware vulnerabilities in products from major manufacturers such as AMI, AMD, Dell, Fujitsu, HP, Insyde, Intel and Lenovo. The startup claims to have identified more than 100 new flaws this year alone.

Are you developing new technology for an existing application? Did you know your development work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? Even if your development isn’t successful your work may still qualify for R&D credits (i.e. you don’t need to have a patent to qualify). To find out more, please contact a Swanson Reed R&D Specialist today or check out our free online eligibility test.

Who We Are:

Swanson Reed is one of the U.S.’ largest Specialist R&D tax advisory firms. We manage all facets of the R&D tax credit program, from claim preparation and audit compliance to claim disputes.

Swanson Reed regularly hosts free webinars and provides free IRS CE and CPE credits for CPAs. For more information please visit us at www.swansonreed.com/webinars or contact your usual Swanson Reed representative.

Gregg Michael Kellett v. Comm’r: A Case in Biotechnology

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Kellett v. Comm’r, T.C. Memo 2022-62 | June 14, 2022 | Greaves, J. | Dkt. No. 21518-18

Summary:

The IRS disallowed a $25,992 business expense deduction resulting in a corresponding deficiency of $6,475 in 2015. 

Kellett ran a business information website which started upon the website’s opening in September 2015. This website compiled demographic, social, and economic data and attempted to make a user-friendly version of Google or Yahoo Finance. The website was developed with engineers who built the desired features and functionality. On a timely filed 1040, the taxpayer claimed expense deductions for these engineers as well as a marketing strategist, cell and internet service cost from his home, and some miscellaneous expenses. The IRS denied all deductions on the grounds that the business had not started.

The Tax Court set out to determine:

  • When does a business start for purposes of § 195?
  • Can a taxpayer expense the costs of developing software under § 174 before the business technically begins, or is he solely relegated to relief under § 195?
  • Can a taxpayer use Rev. Proc. 2000-50 to deduct the costs of developing a website?

Key Points of Law:

  • 195 Start-up Expenditures: § 195(a) disallows deductions for start-up costs except for provided in this section. Therefore, under § 195(b), a taxpayer generally can deduct up to $5,000 of start-up expenditures. However, if the costs are in excess of $50,000, then the amount is phased out dollar for dollar until $55,000. § 195(b)(1)(A)(i)-(ii). Any amount phased out, or in the event the costs exceed $55,000, the taxpayer must capitalize the capital outlay and then amortize it ratably over 15 years. § 195(b)(1)(B).
  • 174 Research and Development: Taxpayers are granted relief from the harsh capitalization standards for start-up costs under § 174, but it applies only in limited circumstances. However, the general rule is that taxpayers may treat R&D connected with their trade or business as expenses not chargeable to the capital account. § 174(a)(1). § 195(c)(1) excludes from the definition of start-up expenditures any amount which a deduction is allowable under § 174.

The Court’s Decision And Learnings:

The court determined the business began in September of 2015 because that is when it began providing the services for which it was organized. Any expenses incurred before this date must be taken under § 195 and any expenses after this date are taken under § 162.

Further review brought the following decision: the taxpayer is disallowed from taking a § 174 deduction (i.e. R&D Tax Credit) since he merely adapted a widely used software rather than developing it from whole cloth.

This case highlights the importance of understanding the difference between development and experimental development. While website or software development may seem as though it is inherently R&D, developers must carefully consider if their product is novel and faces technical uncertainties. Modification of existing software rarely has significant enough technical uncertainty or experimental development work to pass the IRS’s four part test.

Click here to read the full case.

Are you conducting research and development activities? Did you know your development work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? Even if your development isn’t successful your work may still qualify for R&D credits (i.e. you don’t need to have a patent to qualify). To find out more, please contact a Swanson Reed R&D Specialist today or check out our free online eligibility test.

Who We Are:

Swanson Reed is one of the U.S.’ largest Specialist R&D tax advisory firms. We manage all facets of the R&D tax credit program, from claim preparation and audit compliance to claim disputes.

Swanson Reed regularly hosts free webinars and provides free IRS CE and CPE credits for CPAs. For more information please visit us at www.swansonreed.com/webinars or contact your usual Swanson Reed representative.

V-Quad Accepting Applications for $25K Entrepreneurs Technical Assistance Program Grants

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The Mississippi Development Authority has announced the opening of their application process for the Mississippi Energy Program for Innovation Cluster: Virtual Quad (V-Quad). Applications will be accepted from qualified teams developing new products or services in the energy and agriculture technologies.

V-Quad was founded with the mission of building an innovative, virtual incubator network. This network should support Mississippi entrepreneurs and innovators as they launch energy and agriculture-focused technologies.

In building this network, these startups will have access to technical expertise through connections at Mississippi’s research universities, industry government, and nonprofits.

The current applicants will be applying for V-Quad Entrepreneurs Technical Assistance Program (ETAP) grants. If selected, they will be eligible for a maximum award of $25,000 each in vouchers to receive technical assistance from a research university in the state. MDA – who is supported by the U.S. Department of Energy State Energy Program – will award a total of $100,000 in the ETAP.

The teams will be paired with a relevant research university, based on their proposed projects, to tackle specific technical challenges and uncertainties. They will have nine months from the award date to complete these proposed projects.

Examples of eligible projects include the use of clean energy and energy-efficient products and services, agricultural products and services, as well as robotics, artificial intelligence, virtual reality, unmanned aerial and terrestrial vehicles and genomics applied within the energy and agriculture sectors.

Are you developing new technology for an existing application? Did you know your development work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? Even if your development isn’t successful your work may still qualify for R&D credits (i.e. you don’t need to have a patent to qualify). To find out more, please contact a Swanson Reed R&D Specialist today or check out our free online eligibility test.

Who We Are:

Swanson Reed is one of the U.S.’ largest Specialist R&D tax advisory firms. We manage all facets of the R&D tax credit program, from claim preparation and audit compliance to claim disputes.

Swanson Reed regularly hosts free webinars and provides free IRS CE and CPE credits for CPAs. For more information please visit us at www.swansonreed.com/webinars or contact your usual Swanson Reed representative.

West Virginia High Technology Foundation

Solar Panels

The West Virginia High Technology Foundation has announced their plans for two major projects for the I-79 High Technology Park. The first will be a solar test bed aiming to spark growth in renewable energy; the second will be a new NOAA ground station to monitor and collect space weather data.

The Foundation conducts intensive R&D projects in physics, electrical engineering, computer science and related fields for a range of government and industrial customers. With a vast team of experts and scientists, the Foundation acts as an engine of economic change across regional, statewide, and national high-tech business sectors.

The I-79 High Technology Park is their premier location for high priority Federal operations that require advanced electrical and telecommunications infrastructure. The park is located within the heart of the I-79 High Technology Corridor just south of Fairmont, West Virginia.

The team is in the process of finalizing plans for the solar test bed, which will include a 1-megawatt solar grid. The grid should generate energy and be used for testing and evaluation in future projects. The production of the test bed will be completed in collaboration with West Virginia University and FirstEnergy Corp.

The second project will see the construction of a third satellite ground station for NOAA. The other two satellites have proven to be crucial to weather and climate data collecting for years and will benefit from the additional location. The new station will collect a new type of weather data – that of space itself. The new data will be collected from a satellite that will eventually sit in an area of space known as Lagrange 1. This area is a central point between the Earth and the Sun which will allow the satellite to collect data associated with space weather. Space weather impacts Earth’s weather conditions as well as satellite communications. This third station will ensure the foundation has the most comprehensive coverage and collection of climate and weather data across the globe.

The Foundation hopes both of these projects will be completed by the end of the calendar year. Foundation President and CEO Jim Estep believes that both the ground station and the solar test bed could mean huge things for the I-79 High Technology Park and North Central West Virginia in general, and he’s excited to see both projects get up and running.

Are you developing new technology for an existing application? Did you know your development work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? Even if your development isn’t successful your work may still qualify for R&D credits (i.e. you don’t need to have a patent to qualify). To find out more, please contact a Swanson Reed R&D Specialist today or check out our free online eligibility test.

Who We Are:

Swanson Reed is one of the U.S.’ largest Specialist R&D tax advisory firms. We manage all facets of the R&D tax credit program, from claim preparation and audit compliance to claim disputes.

Swanson Reed regularly hosts free webinars and provides free IRS CE and CPE credits for CPAs. For more information please visit us at www.swansonreed.com/webinars or contact your usual Swanson Reed representative.

Venus Aerospace Unveils Stargazer – their first conceptual hypersonic vehicle designed for one-hour global travel

South Dakota Patent of the Month - August 2021

Venus Aerospace, an aerospace startup, has made an exciting announcement at the UP.Summit in Bentonville, Arkansas. The company introduced their first conceptual vehicle design, the “Stargazer”, which will fly from Los Angeles to Tokyo in just an hour.

The Mach 9 hypersonic aircraft has been under development since the company’s founding in 2020. The aircraft’s design is meant to allow it to fly at hypersonic speeds at the edge of the atmosphere.

This kind of design is no joke and requires some serious funding. Venus has been backed by leading venture capitalists and has received $1 million in government funding. The company has stated they have raised over $33 million to build a Mach 9 hypersonic drone and Mach 9 spaceplane – each of which will be capable of one-hour global travel.

Venus has made significant progress since their founding, scaling rapidly in their bid to design and build a demonstration engine. This engine has since been tested in hypersonic wind tunnels and propulsion test facilities across the U.S.. Next tests include their plans to start subsonic and supersonic flight testing of a scaled drone.

With a team of experts including aerospace, military, and R&D veterans, the company is focused on three main technologies: a zero-emission next-generation rocket engine, innovative aircraft shape, and leading-edge cooling.  

This combination of technology could be the key to making one-hour global transport a cost-effective possibility.

Are you developing new technology for an existing application? Did you know your development work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? Even if your development isn’t successful your work may still qualify for R&D credits (i.e. you don’t need to have a patent to qualify). To find out more, please contact a Swanson Reed R&D Specialist today or check out our free online eligibility test.

Who We Are:

Swanson Reed is one of the U.S.’ largest Specialist R&D tax advisory firms. We manage all facets of the R&D tax credit program, from claim preparation and audit compliance to claim disputes.

Swanson Reed regularly hosts free webinars and provides free IRS CE and CPE credits for CPAs. For more information please visit us at www.swansonreed.com/webinars or contact your usual Swanson Reed representative.

US Department of Agriculture Tackles Cercospora Leaf Spot Disease

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Cercospora leaf spot disease is an infectious disease affecting a range of plants in landscapes and nurseries. The disease is the result of the fungus Cercospora beticola and occurs wherever table beets, swiss chard, sugar beet, and spinach are grown and is one of the most important diseases affecting the Chenopodium group. The disease leads to significant losses especially in late summer. The leafy greens become unmarketable and the beet roots fail to grow to full size.

With such an impact, it’s no surprise that plant pathologist, Nathan Wyatt, has committed to researching this disease. The project, which is underway at the U.S. Department of Agriculture’s Agricultural Research Service, will aim to find a way to more efficiently control the disease in sugargeats. It will also look into how to reduce fungicide resistance to the pathogen.

Nathan Wyatt, who works in the Edward T. Schafer Agricultural Research Center’s Northern Crop Science Laboratory in Fargo, North Dakota will be conducted during the next few years to fine tune the model that predicts when the risk of cercospora leaf disease is at a level at which growers can respond by spraying fungicides on the sugarbeets.

The research will focus on looking at the thresholds of relative humidity and temperatures at which you start to see cercospora leaf spots. Wyatt will use that research, which identified weather conditions conducive to cercospora leaf spot disease development, together with new information about asymptomatic infection to devise more specific fungicide predictions.

Currently, the 2022 NDSU sugarbeet production guide recommends that farmers begin spraying fungicides early on and then spray every 10-14 days for the remainder of the season.

Data will be collected this summer, and field trials will get underway in 2023, Wyatt said. The goal is to have prediction models available for sugarbeet cooperatives in 2024.

Are you developing new technology for an existing application? Did you know your development work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? Even if your development isn’t successful your work may still qualify for R&D credits (i.e. you don’t need to have a patent to qualify). To find out more, please contact a Swanson Reed R&D Specialist today or check out our free online eligibility test.

Who We Are:

Swanson Reed is one of the U.S.’ largest Specialist R&D tax advisory firms. We manage all facets of the R&D tax credit program, from claim preparation and audit compliance to claim disputes.

Swanson Reed regularly hosts free webinars and provides free IRS CE and CPE credits for CPAs. For more information please visit us at www.swansonreed.com/webinars or contact your usual Swanson Reed representative.

GeneCure, LLC v. Comm’r: A Case in Biotechnology

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Genecure, LLC v. Comm’r, T.C. Memo 2022-52 | May 23, 2022 | Jones, J. | Dkt. No. 14916-15.

Summary:

GeneCure, LLC is a biotechnology company focused on developing gene therapy based technologies to treat genetic and acquired human diseases. The company developed a patented lentiviral delivery platform which they use to further develop novel human vaccines. The company claimed R&D tax credits for this research and were met with adjustments made by the IRS for the 2009-2012 taxable years.

The opinion set out to address numerous issues including taxation of settlement proceeds received in contract dispute, deductibility of item-by-item categories of business expenses, recapture tax for an Affordable Care Act-Qualified Therapeutic Discovery Project (QTDP) grant received by Genecure, characterization of amounts received from an LLC owned by Frank Tung’s wife (i.e., is it a loan, or not a loan), and possible capital contributions from the LLC owned by Frank Tung’s wife.

Key Points of Law:

This is a TEFRA partnership-level case with GeneCure organized as a member-managed LLC. As such, it is treated as a partnership for federal income tax purposes (Treas. Reg. § 301.7701-3(b)(1)).

The IRS first examined the tax returns for 2009-2012, providing a Form 11661, Fraud Development Recommendation-Examination. They then issued Frank Tung, in his capacity as tax matters partner, a separate Notices of Final Partnership Administrative Adjustment (FPAA) for each of the years in issue, as well as a section 6663 civil fraud penalty for underpayment of tax for each year.

Frank Tung gathered and attempted to admit evidence and documentation including emails and letters from GeneCure’s day-to-day business. Most of this documentation the Tax Court refused to admit or consider. This was due to the irrelevance of the evidence. Tax Court evidentiary rulings are determined under the Federal Rules of Evidence (7453; Rule 143(a)).

The Court’s Decision And Learnings:

Frank Tung, acting as tax matters partner for GeneCure, failed to provide acceptable evidence following evidentiary standards. He also failed to provide available exceptions to the rules and therefore the evidence was not submitted. 

GeneCure failed to document and substantiate most of the claimed business expenses it sought to deduct. They further failed to report taxable income including the amounts received in a settlement from a business contract dispute. Deductions and other tax benefits were claimed but could not be substantiated. They further could not prove that a $200,000 payment from Frank Tung’s wife was a loan for rent.

Because of these failures, the Tax Court ruled in favor of the IRS on all tax issues. They found Frank Tung’s testimony to be self-serving, evasive, conflicted, and improbable. The court’s conclusions were as follows:

  • That Genecure had unreported income of $6,000; $21,578; and $7,000 in taxable years 2009-11, respectively; 
  • That Mr. Tung largely failed to establish Genecure’s entitlement to deductions for various business expenses reported for each of the taxable years at issue; 
  • That Genecure is subject to a $230, 979 recapture tax with respect to its taxable year 2010 for excess amounts received as a QTDP grant;
  • That Mr. Tung failed to substantiate a $200,000 loan to Genecure from Mrs. Tung in taxable year 2009;
  • That Mr. Tung failed to substantiate a $100,000 capital contribution to Genecure from Mrs. Tung in taxable year 2011.

As for the fraud-related penalties, the IRS Civil Penalty Approval Form and its Form 11661 did not satisfy the written supervisory approval requirements for purposes of assessing section 6663 civil fraud penalties; therefore, such penalties were inapplicable against Genecure at the partnership level.

This court case serves as an example of the absolute importance of documentation and substantiation. There are stringent evidentiary requirements which must be considered and having a paper trail to back up any claim is crucial to the vitality of said claim.

Click here to read the full case.

Are you conducting research and development activities? Did you know your development work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? Even if your development isn’t successful your work may still qualify for R&D credits (i.e. you don’t need to have a patent to qualify). To find out more, please contact a Swanson Reed R&D Specialist today or check out our free online eligibility test.

Who We Are:

Swanson Reed is one of the U.S.’ largest Specialist R&D tax advisory firms. We manage all facets of the R&D tax credit program, from claim preparation and audit compliance to claim disputes.

Swanson Reed regularly hosts free webinars and provides free IRS CE and CPE credits for CPAs. For more information please visit us at www.swansonreed.com/webinars or contact your usual Swanson Reed representative.

Flywheel to Serve as Research Platform in Study on Pediatric Brain Development in Low- and Middle-Income Countries

Georgia Patent of the Month - January 2022

Flywheel, founded in 2010, is rapidly emerging as a platform of choice for researchers interested in the use of imaging research and machine learning. The company has recently received a grant from the Bill & Melinda Gates Foundation to support research on the neurodevelopmental health of children growing up in poverty and other adverse environments in low- and middle-income countries (LMICs).

This data management platform has focused on powering healthcare innovation by accelerating collaboration between partners, enabling machine learning, and streamlining the daunting task of data aggregation, curation, and management.

With their unique technology and expertise, the company will utilize the multi-year grant to provide a centralized, cloud-based research infrastructure to an international cohort of researchers led by King’s College London.

The research will be conducted by distributed research teams, each of which will use Flywheel to curate, share, and analyze MRI scans of young children between the ages of 0 and 24 months across 25 LMICs in Africa and Asia. The use of Flywheel is intended to reduce the constant IT burdens and data sharing restrictions normally experienced in multi-site initiatives of this size.

“We are honored to participate in this important project,” said Can Akgun, PhD, Senior Vice President of Business Development at Flywheel. “By leveraging our comprehensive research data solution, the team will now focus on gaining a deeper understanding of pediatric brain development rather than spending valuable time on management of data and computational workflows. We believe this research effort will make a major contribution to improving the health of future generations.”

Are you developing new technology for an existing application? Did you know your development work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? Even if your development isn’t successful your work may still qualify for R&D credits (i.e. you don’t need to have a patent to qualify). To find out more, please contact a Swanson Reed R&D Specialist today or check out our free online eligibility test.

Who We Are:

Swanson Reed is one of the U.S.’ largest Specialist R&D tax advisory firms. We manage all facets of the R&D tax credit program, from claim preparation and audit compliance to claim disputes.

Swanson Reed regularly hosts free webinars and provides free IRS CE and CPE credits for CPAs. For more information please visit us at www.swansonreed.com/webinars or contact your usual Swanson Reed representative.

Submittable Secures Largest-Ever Venture Capital Investment in Montana

Software People

Submittable, the software company focused on helping nonprofits, governments and corporations accelerate their social impact work, has just secured Montana’s largest-ever venture capital investment.

The Missoula-based company has announced the close of its Series C funding with a successful investment of $47 million in funding. The round was led by Accel-KKR with support from existing investors.

The company’s next steps will see the funding go towards growing their team with the intention of doubling staffing. After doubling revenue in the year prior, the capital will support the much needed labor to effectively scale.

Submittable was founded in 2010 by local entrepreneurs Michael FitzGerald, Bruce Tribbensee and John Brownell. After 9 years of dedicated R&D and commercialization, the company secured $10 million in venture capital.

Thor Culverhouse, CEO of Submittable, said the social impact sector has experienced “unheard-of” growth in recent years as public, private and nonprofit entities have all increased the funding going towards justice, equity, diversity and inclusion.

Submittable’s technology provides a start-to-finish grants management platform to simplify and streamline the process of applying for and tracking grants. The platform allows users to track the entire initiative from the first grant application to the final report using workflow automation, funds distribution services, and reporting tools. 

In 2020, the state government of Montana used Submittable’s platform to roll out multiple grants to distribute federal CARES Act funding to businesses and individuals impacted by the pandemic.

This record-breaking funding round could have great implications for the state, bringing more high-paying jobs and investments to the region. It may even inspire local entrepreneurs to maintain their roots and grow their ideas right at home.

Are you developing new technology for an existing application? Did you know your development work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? Even if your development isn’t successful your work may still qualify for R&D credits (i.e. you don’t need to have a patent to qualify). To find out more, please contact a Swanson Reed R&D Specialist today or check out our free online eligibility test.

Who We Are:

Swanson Reed is one of the U.S.’ largest Specialist R&D tax advisory firms. We manage all facets of the R&D tax credit program, from claim preparation and audit compliance to claim disputes.

Swanson Reed regularly hosts free webinars and provides free IRS CE and CPE credits for CPAs. For more information please visit us at www.swansonreed.com/webinars or contact your usual Swanson Reed representative.