Advanced Regenerative Manufacturing Institute Awarded $51M to Assist in Developing Technical Health Solutions

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The Advanced Regenerative Manufacturing Institute (ARMI) is responsible for developing and manufacturing large-scale engineered tissues and tissue-related technologies to benefit existing and future industries. The U.S. Department of Health and Human Services has recently announced that ARMI will receive a $51 million grant from the Federal Government to develop portable technology to produce medications and vaccines in an effort to expand access to “critical medical care in places where drugs are logistically and financially difficult to deliver”.

The grant will allow for major biotechnical innovation to fight health security threats and pioneer life-changing scientific advancements to change the face of medicine. Products and developments that will surface from this grant will allow the U.S to recover faster from natural disasters and other health emergencies.

The $51 million grant will be distributed over a five-year period, with U.S Senator Jeanne Shaheen recognizing the importance of the grant in “[attracting] and [retaining] the next generation of innovators”, as well as provide “good-paying jobs…[and] further strengthen the economy”.
ARMI will engage with regional experts and offer an idea lab, dry and wet labs, manufacturing space, and a learning zone, while also creating and managing a commercialization program that engages in private-sector partners to accelerate the adoption of the technologies.

ARMI’s first project will focus on maturing and validating small, portable, automated devices that could be transported easily to disaster locations to make necessary medicines available on-site.

Gloria Jean’s Coffee Set to Expand its Franchise

Expand Franchise

Globally recognised cafe chain, Gloria Jean’s Coffee – U.S.A has decided to expand its reach in Indiana. The company signed a multi-unit development agreement with a new franchise partner, Raed Naser allowing the new partner to open as many as seven new locations in Northwest Indiana and another 20 across greater Chicago.

To keep meeting its customer’s expectations, Gloria Jean’s carefully selects Arabica Beans from judicious sources around the works, then determines their suitability at its Southern California Headquarters, which includes a test kitchen where it partakes in R&D projects managed by a Cordon Bleu-trained chef.

By investing more in R&D and coupling those efforts with their market experience, Gloria Jean’s intends to improve and solidify its proven global operating system.

“With a refreshed brand image and four decades of experience in the specialty coffee industry, Gloria Jean’s is in growth mode and uniquely positioned to own a larger share of the segment, especially in riding suburban markets like Northwest Indiana and Southern Chicago,” said Laina Sullivan, Gloria Jean’s Coffees’ Director of Franchise Development. “We’re thrilled to welcome passionate franchise partners like Raed to the Gloria Jean’s family during this exciting brand evolution. As we pursue strategic growth outside of malls and move into regions where customer demand for exceptional specialty coffee is high, we see tremendous opportunity to introduce Gloria Jean’s to new guests around the country.”

Since purchased by the Australia-based Retail Food Group in 2014.  The brand has been finding opportunities to expand in multiple locations. By investing in R&D, Gloria Jeans is aiming to grow the franchise portfolio.

Nestlé Unveils a New R&D Accelerator Program to Boost Product and Systems Innovation

Nestlé accelerator program

Nestlé, a key player in the global Food & Beverage Industry recently created an accelerator program that aims to bring students, startup enterprises, and the company’s scientists together to develop innovative products and systems.

The first research team has already been selected, and the unit is expected to be fully operational by the end of this year.

Nestlé promised all selected teams (whether external, internal or mixed) will have full access to the company’s R&D expertise and infrastructure, including equipment, kitchens and shared labs.

“We have taken a number of steps to accelerate innovation, including out enhanced prototyping capabilities and the funding of fast track projects. With the Nestlé R&D Accelerator and its proximity to our R&D and business teams, we will bring open innovation to a new level,” said Stefan Palzer, Nestlé’s Chief Technology Officer.

“Combining our internal expertise and the deep knowledge of our academic and industrial partners with the external entrepreneurial creativity is a unique approach and will create an innovation powerhouse. It will accelerate the translation of innovative ideas and concepts into tangible prototypes and products.”

Announced at the beginning of 2019, the R&D accelerator is part of Nestlé’s global R&D network and will be based in Lausanne, Switzerland, the same location as Nestlé’s R&D focused research center.

In fact, the company claims to have the largest private Food and Nutrition R&D organisation involving 23 sites and more than 4,200 individuals around the world.

According to Nestlé, Core to the accelerator teams’ work is user research, design thinking, prototyping and digital acceleration. This will help those who come up with concepts to refine their ideas before pitching them to executives for seed funding.

Part of the program’s contributing partners includes academic institutions like the Swiss Hospitality Management School in Lausanne and Swiss Federal Institutes of Technology in Zurich and Lausanne.

Global Microbiology Industry Projected to Grow Due to R&D Expenditure and Innovation

Global Microbiology Industry Projected to Grow Due to R&D Expenditure and Innovation

Increasing R&D interest and innovation in industrial microbiology has seen it being utilised in a growing number of industries including oil and gas, natural environment research and the food industries.

Due to the recent upsurge in biopharmaceutical drug developments, the industrial microbiology is projected to follow and grow exponentially within the next few years.

Increased interest and demand in nutraceuticals and fermented products, creates new demands for industrial application of microbiology will increase.

Uses of microbes in the food and beverage industry is expected to maintain the largest share as the industry is trying to revolutionise the microbiological application in various packaging process, fermentation and beneficial microbes in food (probiotics and prebiotics). Furthermore, microbes are also beneficial to testing, stabilising and transforming organic materials.  

Since microbiology is so involved in various other innovative industries heavily relying on a chain reaction of each other’s research results, there is growing support from the United States Food and Drugs Administration (US FDA) and Canada Health.

The US industrial microbiology market is expected to continuously grow with a peak between 2020 and 2024. The potentials of this industry should encourage researchers to be innovative and engage in various R&D projects.

If your company is involved with R&D contact us here to see how we can help you.

Scientist Develop a Computer Tool For Predicting Fatal, Irregular Heart Beats

life saving devices fall risk

Heart-related diseases remain one of the leading causes of death worldwide. In most medical cases, these ailments affect the electrical function of the heart, which in turn, leads to lethal and irregular heart beats (also known as arrhythmias.)

Doctor’s current understanding of the intricate issues that shape the beating heart’s electrical function is still inadequate to prevent these often devastating and common diseases.

That said, the good news is, researchers recently created a computer software that can precisely predict which individuals with the rare heart condition may suffer from a potentially fatal event in the future, and whether they will benefit from lifesaving implanted devices.

The computer system, developed by an international team led by scientists from John Hopkins University in the United States, might also help doctors to avoid unnecessary (and sometimes risky) surgeries to place the implanted devices.

During the research, the scientists concluded that 1 in every 5,000 people suffer from Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC). This is an inherited, complex, and multi-gene ailment of the lower heart chambers that can result in irregular heartbeats or deadly arrhythmias.

In most cases, doctors can effectively manage ARVC using the implantable cardioverter-defibrillator (ICD); which is a battery powered tool placed beneath the skin to help keep track of one’s heart rate. Thin wires connect your heart to the ICD.

If the ICD detects an abnormal heart rhythm, it (the ICD) delivers an electric shock that will restore the normal heart beat. These devices have been extremely useful in preventing abrupt deaths in patients with sustained ventricular tachycardia.

Having said that, ICDs retail with their fair share risk and side effects as well. For starters, the device may make an error and deliver an inappropriate shock when the patient isn’t experiencing life-threatening arrhythmia.  

Second, the tool usually fails over time, requiring you to visit the hospital for replacement surgeries. This results in hospitalizations and expenses that can skyrocket up to $20,000 per replacement.

“Because patients develop this condition at such a young age, they typically need several ICD replacements over the course of their lives,” adds James, who is also a member of the Precision Medicine Center for Excellence for Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) and Complex Arrhythmias, part of Johns Hopkins InHealth, the precision medicine effort at the Johns Hopkins University School of Medicine. “For ARVC patients, getting an ICD is a big decision with serious consequences.”

“If someone is at risk of sudden cardiac death, you don’t want to miss the chance of putting in a lifesaving device. But you also don’t want to put it in if that risk is not worth taking,” says Hugh Calkins, M.D., professor of cardiology at the Johns Hopkins University School of Medicine and director of the Electrophysiology Laboratory and Arrhythmia Service at The Johns Hopkins Hospital. “This new model can help doctors and patients decide better if an ICD is warranted on a case-by-case basis,” he adds.

Access to Rapid Magnetic 3D Printing of Human Cells May Revolutionize Research Labs

Medicine

The development of 3D printing within the biological sector may mean the end of using animals for medical testing.

Earlier this year, a team of engineers from McMaster University in Canada developed a 3D printing technique that uses magnets to rapidly create artificial tumors which allows researchers to test new therapies and drugs.

This invention will also allow for personalized medications to match symptoms, instead of receiving the standardised one-size-fits-all treatments, as 3D printed cells can be manipulated to suit different researches.

The Engineers believe this new technique will allow researchers to create accurate 3D cell clusters with various cells layers to better match conditions inside the human body for regenerative medicine research.

According to a study published in Science Partner Journal, they (the engineers) were able to print 3D cancer tumor cells within six hours using the method.

If this method is to be successful,  this will eliminate the need for animals during studies altogether. After all, replicating 3D structures of human tissues will give researchers more accurate information about a medication’s results as it is closer to human biology than using animals.

The technology will also speed up the process of drug development by replacing the simpler testing on human cells in Petri dishes; further saving hundreds of millions of dollars from getting wasted on unsuccessful drug candidates that fail during human clinical trials.

“We have developed an engineering solution to overcome current biological limitations. It has the potential to expedite tissue engineering technology and regenerative medicine,” said Sarah Mishriki, a Ph.D. candidate in the School of Biomedical Engineering and lead author. “The ability to rapidly manipulate cells in a safe, controllable and non-contact manner allows us to create the unique cell landscapes and microarchitectures found in human tissues, without the use of a scaffold.”

“This magnetic method of producing 3D cell clusters takes us closer to rapidly and economically creating more complex models of biological tissues, speeding discovery in academic labs and technology solutions for industry,” said Rakesh Sahu, a research associate.

US Energy Department to Invest in Blockchain Technology as New Security Measure

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The U.S. Department of Energy is exploring blockchain technology as a new defence measure against cyberattacks in phase two of a nationwide project to upgrade power plant security.

Blockchain is a system that allows transactions to be made in cryptocurrency, maintained across several computers or servers. By decentralisation the cybersecurity concerns and only being linked to a peer – peer network. Blockchain technology makes it much harder to hack into than standard cyber security measures.

It was announced recently by the department’s National Energy Technology Laboratory (NETL) that development in the electric grid security project will focus on decentralised cybersecurity. Startup company Taekion, specialising in this field has been granted $1 million last year in R&D incentives and now will be focusing on researching how blockchain technology can be implemented as a new line of defence.

The NETL said: “The applications being developed in the NETL-managed project have the potential to thwart such attacks by preventing hackers from altering the plant’s operational information.”

A cyberattack on a power plant in Ukraine in 2016 has shown. The severity of such attacks as it resulted in power outages around the country. Such technology to prevent attacks like this are still in the early stages of development. Projects funded by the Department exploring this technology is funded by the department’s Small Business Innovation Research program.

This is not the first time the NETL has invested in research to explore the potential of blockchain energy for technological improvements in the security between power plants and grids within the nation. In 2017, they partnered with another technological company to explore using blockchain in higher security between transactions.

It has also been announced universities will receive fundings of up to $4.8 million for working on R&D blockchain projects.

Up to $7 Million R&D Incentive for Offshore Wind R&D

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New developments and research to America’s offshore wind energy industry will receive a significant books as the US government will provide up to USD $7 million in funding. The funding will be invested in research on new technologies aiming to reduce the costs for developing offshore projects.

Targeted projects will be looking at reducing time and cost  in the implementation of offshore projects. Strategically as this is still a new American industry the R&D Incentive will be critical to its Advancements.  

Nils Bolgen, director of Massachusetts Clean Energy Centre said “ this solicitation provides important resources that will help connect our research and testing community with industry players, driving innovation.”

Revitalizing the Manufacturing Industry

smart manufacturing

The Clean Energy Smart Manufacturing Innovation Institute (CESMII) aims to build value in the manufacturing industry by taking advantage of smart technologies including software and sensors. CEO John Dyck says that the institute intends to revitalize US and global manufacturing by tackling the challenges that come with implementing these new technologies, as well as the company data flow issues. For instance, CESMII have developed a basic set of technologies for manufacturers and are funding six month projects to solve specific problems, up to a value of $250,000.

Based in California, the institute is developing regional centers across the US including Texas, New York and plans to expand to the Midwest over the coming year. These regional centers will allow for greater industry specialization.

Ohio could well become home to the new manufacturing center as Dyck lives in Northeast Ohio himself. He stated that, “Not having a presence in the Rust belt is a huge strategic gap.” Furthermore, a potential collaboration with business development organization, Team NEO, may be in the works. Team NEO is interested in increasing Ohio’s adoption of smart manufacturing technology in order to maintain a competitive edge.

CESMII is the ninth manufacturing innovation institute to be developed by the government in order to encourage advanced manufacturing R&D. They attempt to assist manufacturers by organizing support from academics, application vendors and system integrators to solve current issues, with the solutions becoming open-source once completed.

New Monoclonal Antibody Drug One Step Closer to New Breakthrough

pharmaceutical

Some of the biggest pharma giants are coming together to drive the surge in the development of the next generation of antibodies. A new study on the monoclonal antibody therapy is one step closer to treating rare diseases. Analysts predict breakthroughs and research within this market will increase revenues to $140 billion in 2022.  

The US alone invests approximately $45 billion annually within the drug industry with the majority of research in biologics. Overall, the global pharmaceutical market at US$934.8 billion is predicted to be US$1.17trillion in 2021 thanks to innovate studies catalysed by R&D incentives.

Being so innovative and relying heavily on research and development, the pharmaceutical industry is closely intertwined with many discovery platforms including but not limited to:

  • Environmental Science
  • Physiology
  • Natural Science

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